Title

Racial Differences Among Factors Associated with Participation in Clinical Research Trials.

Publication/Presentation Date

9-8-2016

Abstract

OBJECTIVE: To identify whether racial differences exist among various factors associated with patients' decision to participate in clinical research trials.

METHODS: A self-administered, IRB-approved survey was utilized with inclusion criteria requiring subjects to be 18 years of age or older, having active patient status and ability to complete the survey without assistance. Subjects were asked to rate potential influential motivators, barriers, and facilitators on a "no influence" (0) to "most influence" (4) scale for participation in research that tests a new drug or device. Kruskal-Wallis testing was used to identify factors significantly associated with race.

RESULTS: Analysis included 1643 surveys: 949 (57.8 %) Caucasian; 217 (13.2 %) African-American; 317 (19.3 %) Hispanic; 62 (3.8 %) Multiracial; and 98 (6.0 %) "Other" minorities. Statistically significant differences (p ≤ .02) by race were found for five out of ten motivating factors. "How well the research study is explained to me" had the highest mean value for all races except other minorities, for whom "Knowledge learned from my participation will benefit someone in the future" scored highest. "Risk of unknown side-effects" was the greatest barrier for all races.

CONCLUSION: Racial differences exist not only between Caucasians and Minorities for the factors associated with their clinical trial participation, but also among different minority races themselves. To promote diversity in research, recruitment strategies for each individual race should be customized based on what matters to the target population.

ISSN

2196-8837

Disciplines

Emergency Medicine | Family Medicine | Infectious Disease | Medicine and Health Sciences | Nursing | Obstetrics and Gynecology

PubMedID

27631379

Department(s)

Department of Emergency Medicine, Department of Emergency Medicine Faculty, Department of Family Medicine, Department of Family Medicine Faculty, Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology Faculty, Patient Care Services / Nursing, Patient Care Services / Nursing Faculty

Document Type

Article