Title

Economic and Clinical Burden of Opioid-Induced Nausea and Vomiting.

Publication/Presentation Date

1-1-2017

Abstract

Opioids are the standard of care for treating moderate-to-severe pain; however, their efficacy can be limited by adverse events (AEs), including nausea and vomiting. Opioid-induced nausea and vomiting (OINV) is an inherent adverse effect of opioid treatment, exerting effects centrally and peripherally. Opioid-related AEs can impact treatment adherence and discontinuation, which can result in inadequate pain management. OINV may persist long-term, negatively affecting patient functional outcomes, physical and mental health, patient satisfaction, and overall costs of treatment. Multiple factors may contribute to OINV, including activation of opioid receptors in the chemoreceptor trigger zone, vestibular apparatus, and gastrointestinal tract. Prophylactic or early treatment with antiemetics may be appropriate for patients who are at high risk for OINV.

Volume

129

Issue

1

First Page

111

Last Page

117

ISSN

1941-9260

Disciplines

Anesthesiology | Medical Sciences | Medicine and Health Sciences

PubMedID

27690715

Department(s)

Department of Medicine, Department of Medicine Faculty, Department of Anesthesiology

Document Type

Article