Slowing Progression Along the Renal Disease Continuum.
Publication/Presentation Date
4-1-2005
Abstract
Patients in whom nephropathy develops as a result of hypertension or diabetes mellitus are more likely to die of cardiovascular disease (CVD) than of kidney disease. An early sign of impending nephropathy is microalbuminuria, defined as urinary excretion of albumin at a rate of 28.8 mg/24 h to 288 mg/24 h. Microalbuminuria is a marker of endothelial dysfunction, vascular injury, and renal disease and CVD, and it is associated with increased risk for myocardial infarction. Oxidative stress and endothelial dysfunction are unifying factors mediated by the renin-angiotensin system in renal disease and CVD. Clinical trials show reduced cardiovascular risk and a reversal of microalbuminuria with the use of agents that affect the renin-angiotensin system: angiotensin-receptor blockers in patients with type 2 diabetes mellitus and nephropathy, or angiotensin-converting enzyme inhibitors in patients with type 1 diabetes mellitus.
Volume
105
Issue
4
First Page
207
Last Page
215
ISSN
0098-6151
Published In/Presented At
Kopyt, N. P. (2005). Slowing progression along the renal disease continuum. The Journal Of The American Osteopathic Association, 105(4), 207-215.
Disciplines
Medical Sciences | Medicine and Health Sciences | Nephrology
PubMedID
15928338
Department(s)
Department of Medicine
Document Type
Article