Sex Differences in Fluorouracil-Induced Stomatitis.
PURPOSE: A meta-analysis of six North Central Cancer Treatment Group (NCCTG) trials involving patients receiving their first ever fluorouracil (5-FU)-based chemotherapy was undertaken to explore the association of sex with reports of the incidence and severity of stomatitis.
PATIENTS AND METHODS: Data were obtained on a total of 731 patients (402 men and 329 women). Comparisons of incidence and severity rates and average stomatitis across sex were performed using standard binomial testing and t tests, respectively. Logistic regression analysis and a weighted analysis using data summarized to study level served as evidence of cross-validation.
RESULTS: Women reported stomatitis both more often and with greater severity than did men. The incidence of any stomatitis for women was 63% versus 52% for men (P =.002). The incidence of severe or very severe stomatitis for men and women was 22% and 12%, respectively (P =. 0006). On average, women reported stomatitis of roughly 0.4 points higher than men on a 0 to 4 ordinal scale (P/= 1, (70% v 59%, respectively; P
CONCLUSION: More women than men reported 5-FU-induced stomatitis. The precise mechanism resulting in different degrees of stomatitis across sex is not evident.
Published In/Presented At
Sloan, J. A., Loprinzi, C. L., Novotny, P. J., Okuno, S., Nair, S., & Barton, D. L. (2000). Sex differences in fluorouracil-induced stomatitis. Journal Of Clinical Oncology: Official Journal Of The American Society Of Clinical Oncology, 18(2), 412-420.
Hematology | Medical Sciences | Medicine and Health Sciences | Oncology
Department of Medicine, Hematology-Medical Oncology Division