Title

Sex Differences in Fluorouracil-Induced Stomatitis.

Publication/Presentation Date

1-1-2000

Abstract

PURPOSE: A meta-analysis of six North Central Cancer Treatment Group (NCCTG) trials involving patients receiving their first ever fluorouracil (5-FU)-based chemotherapy was undertaken to explore the association of sex with reports of the incidence and severity of stomatitis.

PATIENTS AND METHODS: Data were obtained on a total of 731 patients (402 men and 329 women). Comparisons of incidence and severity rates and average stomatitis across sex were performed using standard binomial testing and t tests, respectively. Logistic regression analysis and a weighted analysis using data summarized to study level served as evidence of cross-validation.

RESULTS: Women reported stomatitis both more often and with greater severity than did men. The incidence of any stomatitis for women was 63% versus 52% for men (P =.002). The incidence of severe or very severe stomatitis for men and women was 22% and 12%, respectively (P =. 0006). On average, women reported stomatitis of roughly 0.4 points higher than men on a 0 to 4 ordinal scale (P/= 1, (70% v 59%, respectively; P

CONCLUSION: More women than men reported 5-FU-induced stomatitis. The precise mechanism resulting in different degrees of stomatitis across sex is not evident.

Volume

18

Issue

2

First Page

412

Last Page

420

ISSN

0732-183X

Disciplines

Hematology | Medical Sciences | Medicine and Health Sciences | Oncology

PubMedID

10637257

Department(s)

Department of Medicine, Hematology-Medical Oncology Division

Document Type

Article