Title

Red cell Distribution Width and Risk of Cardiovascular Mortality: Insights from National Health and Nutrition Examination Survey (NHANES)-III.

Publication/Presentation Date

4-1-2017

Abstract

INTRODUCTION: Red cell distribution width (RDW) has been linked to cardiovascular disease. We sought to determine whether addition of RDW improved the Framingham risk score (FRS) model to predict cardiovascular mortality in a healthy US cohort.

METHODS: We performed a post-hoc analysis of the National Health and Nutritional Examination Survey-III (1988-94) cohort, including non-anemic subjects aged 30-79years. Primary endpoint was death from coronary heart disease (CHD). We divided the cohort into three risk categories:20%. RDW>14.5 was considered high. Kaplan-Meier survival curves and Cox proportional hazards models were created. Discrimination, calibration and reclassification were used to assess the value of addition of RDW to the FRS model.

RESULTS: We included 7005 subjects with a mean follow up of 14.1years. Overall, there were 233 (3.3%) CHD deaths; 27 (8.2%) in subjects with RDW>14.5 compared to 206 (3.1%) in subjects with RDW≤14.5 (p

CONCLUSIONS: Our study demonstrates that RDW is a promising biomarker which improves prediction of cardiovascular mortality over and above traditional cardiovascular risk factors.

Volume

232

First Page

105

Last Page

110

ISSN

1874-1754

Disciplines

Cardiology | Medical Sciences | Medicine and Health Sciences

PubMedID

28117138

Department(s)

Department of Medicine, Cardiology Division

Document Type

Article