Title

Evaluation of different mixing study reagents and dilution effect in lupus anticoagulant testing.

Publication/Presentation Date

3-1-1991

Abstract

Until recently, the laboratory identification of lupus anticoagulants (LA) was not considered important. Often LA were regarded as a nuisance, resulting in factor assays and other coagulation tests with inconclusive results. However, the recognition of important clinical complications associated with the presence of LA has resulted in an emphasis on the detection of this phospholipid-dependent inhibitor. Most studies have evaluated the sensitivity of various screening or confirmatory procedures used in establishing the diagnosis of LA. The authors have focused on the variables involved in the mixing studies used to identify the presence of a circulating inhibitor. To detect the latter, attention to the ratio of patient plasma to normal plasma is important, particularly in the case of a minimally prolonged APTT. Also the source of "normal" plasma must be platelet poor to maximize sensitivity in the case of a weak LA.

Volume

95

Issue

3

First Page

408

Last Page

411

ISSN

0002-9173

Disciplines

Medical Sciences | Medicine and Health Sciences

PubMedID

1899962

Department(s)

Department of Medicine, Department of Pathology and Laboratory Medicine

Document Type

Article