Increased Mortality Among Patients with Acute Leukemia Admitted on Weekends as Compared to Weekdays.

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The association between weekend admission and patient outcomes has been reported in several acute illnesses, but is unknown in acute leukemia.


We used the 2002-2014 Nationwide Inpatient Sample to identify patients admitted with a primary diagnosis of acute leukemia. Admissions were classified as weekend or weekday admissions for comparison. Hierarchical logistic regression models were used to analyze predictors of hospital-mortality.


There was a 22.3% decline in acute leukemia admissions in 2014 compared to 2002 and a 4% decline in in-hospital mortality (19.0% to 14.9%; p<0.001). 82,833 admissions were included in the study, and 14,241 (17.19%) occurred over the weekend. Hospital mortality was higher for weekend than weekday admissions (18.8% vs. 16.1%; p<0.001). Weekend admissions were less likely to receive early bone marrow biopsy than their weekday counterparts (27.5% vs. 46.3%; p<0.01). Bone marrow biopsy (adjusted odds ratio 0.36, 95% CI 0.33-0.39; p<0.001) and admissions to a teaching hospital (adjusted odds ratio (aOR) 0.65, 95% CI 0.56-0.75; p<0.001) independently predicted lower hospital-mortality. Weekend admission was associated with higher hospital-mortality (aOR 1.12, 95 CI, 1.02-1.23; p=0.01) and more complications than weekday admissions (50.6% vs. 47.8%; p<0.001).


There was significantly increased mortality among weekend admissions for acute leukemia. Mortality was reduced among patients admitted to teaching hospitals.


Cardiology | Medical Sciences | Medicine and Health Sciences


Department of Medicine, Cardiology Division

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