Title

Cognitive Function in Ambulatory Patients with Systolic Heart Failure: Insights from the Warfarin versus Aspirin in Reduced Cardiac Ejection Fraction (WARCEF) Trial.

Publication/Presentation Date

1-1-2014

Abstract

We sought to determine whether cognitive function in stable outpatients with heart failure (HF) is affected by HF severity. A retrospective, cross-sectional analysis was performed using data from 2, 043 outpatients with systolic HF and without prior stroke enrolled in the Warfarin versus Aspirin in Reduced Cardiac Ejection Fraction (WARCEF) Trial. Multivariable regression analysis was used to assess the relationship between cognitive function measured using the Mini-Mental Status Exam (MMSE) and markers of HF severity (left ventricular ejection fraction [LVEF], New York Heart Association [NYHA] functional class, and 6-minute walk distance). The mean (SD) for the MMSE was 28.6 (2.0), with 64 (3.1%) of the 2,043 patients meeting the cut-off of MMSEcovariates, 6-minute walk distance (β-coefficient 0.002, p

Volume

9

Issue

11

First Page

113447

Last Page

113447

ISSN

1932-6203

Disciplines

Cardiology | Medical Sciences | Medicine and Health Sciences

PubMedID

25426862

Department(s)

Department of Medicine, Cardiology Division, Department of Medicine Faculty

Document Type

Article