Title

Circulating Levels of sFlt1 Splice Variants as Predictive Markers for the Development of Preeclampsia.

Publication/Presentation Date

1-1-2015

Abstract

Angiogenic biomarkers, including soluble fms-like tyrosine kinase 1 (sFlt1), are thought to be predictors of preeclampsia onset; however, improvement is needed before a widespread diagnostic test can be utilized. Here we describe the development and use of diagnostic monoclonal antibodies specific to the two main splice variants of sFlt1, sFlt1-1 and sFlt1-14. These antibodies were selected for their sensitivity and specificity to their respective sFlt1 isoform in a capture ELISA format. Data from this pilot study suggest that sFlt1-1 may be more predictive of preeclampsia than total sFlt1. It may be possible to improve current diagnostic platforms if more specific antibodies are utilized.

Volume

16

Issue

6

First Page

12436

Last Page

12453

ISSN

1422-0067

Disciplines

Medical Sciences | Medicine and Health Sciences

PubMedID

26042465

Department(s)

Department of Medicine, Department of Medicine Faculty

Document Type

Article