1,25-Dihydroxyvitamin D-Mediated Hypercalcemia in a Patient With Maligancy Without Lymphoma

Publication/Presentation Date

7-2015

Abstract

Introduction: Hypercalcemia resulting from calcium homeostasis imbalance is seen in one-third of malignancies. Solid malignancies cause hypercalcemia from high parathyroid hormone-related peptide (PTHrP) and, infrequently, from osteolytic cytokines. Excessive 1, 25-dihydroxyvitamin D, seen mostly in lymphoma, causes hypercalcemia by 1-alpha-hydroxylation of 25-hydroxyvitamin D. This mechanism has also been reported in a few cases of dysgerminoma, myofibroblastic tumors, and gastrointestinal stromal tumors.
Case Report: We present an unusual case of 1,25-dihydroxyvitamin D mediated hypercalcemia in a 62-year-old male with colonic adenocarcinoma and mesothelioma.
Conclusion: This case emphasizes that elevated 1,25-dihydroxyvitamin D may be a hypercalcemia etiology in non-lymphoma malignancies and should to be considered when workup for elevated PTHrP and osteolytic hypercalcemia is negative.

Volume

6

Issue

7

First Page

406

Last Page

406

ISSN

0976-3198

Comments

Edorium Journals

Disciplines

Medical Sciences | Medicine and Health Sciences

Peer Reviewed for front end display

Peer-Reviewed

Department(s)

Department of Medicine, Department of Medicine Faculty, Department of Medicine Fellows and Residents

Document Type

Article

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