Title

Drug Eluting Stents Versus Bare Metal Stents For the Treatment of Extracranial Vertebral Artery Disease: a Meta-Analysis.

Publication/Presentation Date

8-1-2016

Abstract

BACKGROUND: While a growing number of reports offer evidence for the potential of drug eluting stents (DES) in treating atherosclerotic stenosis of the extracranial vertebral artery, their efficacy when compared with bare metal stents (BMS) is uncertain due to the lack of a large prospective randomized trial.

METHODS: A search strategy using the terms 'stents', 'drug-eluting stents', 'atherosclerosis', 'vertebral artery', and 'vertebrobasilar insufficiency' was employed through Medline. Five studies met the criteria for a comparative meta-analysis. The technical/clinical success, periprocedural complications, target vessel revascularization (TVR), rates of restenosis, recurrent symptoms, and overall survival were compared.

RESULTS: There was no significant difference in the technical success (OR=1.528, p=0.622), clinical success (OR=1.917, p=0.274), and periprocedural complications (OR=0.741, p=0.614) between the two groups. An OR of 0.388 for no restenosis in the BMS to DES arms (p=0.001) indicated a significantly higher restenosis rate in the BMS group relative to the DES group (33.57% vs 15.49%). When compared with the DES group, the BMS group had a significantly higher rate of recurrent symptoms (2.76% vs 11.26%; OR=3.319, p=0.011) and TVR (4.83% vs 19.21%; OR=4.099, p=0.001).

CONCLUSIONS: A significantly lower rate of restenosis, recurrent symptoms, and TVR was noted in the DES group compared with the BMS group.

Volume

8

Issue

8

First Page

770

Last Page

774

ISSN

1759-8486

Disciplines

Medical Sciences | Medicine and Health Sciences | Neurology

PubMedID

26180094

Department(s)

Department of Medicine

Document Type

Article