Title

Comprehensive Amniotic Fluid Cytokine Profile Evaluation in Women with a Short Cervix: which Cytokine(s) Correlates Best with Outcome?

Publication/Presentation Date

9-1-2009

Abstract

OBJECTIVE: The objective of this study was to determine whether an expanded amniotic fluid cytokine profile predicts spontaneous preterm birth in patients with short cervix in the midtrimester.

STUDY DESIGN: Amniocentesis was performed on singleton gestations between 16-24 weeks with a cervical length

RESULTS: Forty-four amniotic fluid samples were analyzed. After stepwise regression, only monocyte chemotactic protein-1 remained significant and was the most predictive of early delivery. With a cutoff of 1320 pg/mL, monocyte chemotactic protein-1 had a 69% sensitivity, 83% specificity, 36% positive predictive value, and 87% negative predictive value to predict spontaneous preterm birth within 1 week of amniocentesis (P = .015).

CONCLUSION: Among 25 cytokines, monocyte chemotactic protein-1 was most predictive of spontaneous preterm birth.

Volume

201

Issue

3

First Page

1

Last Page

6

ISSN

1097-6868

Disciplines

Obstetrics and Gynecology

PubMedID

19733278

Department(s)

Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology Faculty

Document Type

Article