Is Midtrimester Short Cervix a Sign of Intraamniotic Inflammation?
OBJECTIVE: We sought to determine the relationship between the degree of cervical shortening and intraamniotic inflammation in patients presenting with a midtrimester short cervix.
STUDY DESIGN: Amniocentesis was performed on singleton pregnancies between 16-24 weeks' gestation with a sonographic cervical length (CL)
RESULTS: In all, 109 amniotic fluid samples were analyzed. Most (21 of 25) cytokines were inversely correlated to CL. Monocyte chemotactic protein (MCP)-1 was the most significant by stepwise regression. Using a cutoff of MCP-1 > 1500 pg/mL, CL of 5 mm had an 86% sensitivity, 85% specificity, 58% positive predictive value, and 96% negative predictive value to predict elevated MCP-1 levels. After excluding patients with intraamniotic infection or labor, findings were similar.
Published In/Presented At
Kiefer, D. G., Keeler, S. M., Rust, O. A., Wayock, C. P., Vintzileos, A. M., & Hanna, N. (2009). Is midtrimester short cervix a sign of intraamniotic inflammation?. American Journal Of Obstetrics And Gynecology, 200(4), 374.e1-5. doi:10.1016/j.ajog.2009.01.047
Obstetrics and Gynecology
Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology Faculty