Title

Abdominal Instillation of High-Molecular-Weight Dextran or Lactated Ringer's Solution After Laparoscopic Surgery. A Randomized Comparison of the Effect on Weight Change.

Publication/Presentation Date

7-1-1991

Abstract

Abdominal fluid retention after the instillation of lactated Ringer's solution into the abdomen after operative laparoscopy was evaluated by comparing the serial weights of patients receiving lactated Ringer's after surgery to those of patients treated with the abdominal instillation of high-molecular-weight dextran and to those of negative controls. Twenty-four patients were randomized to receive either lactated Ringer's or high-molecular-weight dextran after operative laparoscopy. Patients undergoing only diagnostic laparoscopy served as negative controls. Patients receiving either lactated Ringer's or high-molecular-weight dextran had increased weights as compared to the negative controls for at least 36 hours (P less than .5), although the weight gain in the treatment groups did not differ statistically significantly. The weight gain remained significantly greater than in the negative controls on postoperative days 3 and 4 in patients treated with dextran. Since the "flotation" effect of dextran in preventing pelvic adhesions is likely to be most pronounced in the immediate postoperative period, the findings suggest the need for a reinterpretation of adhesion prevention studies in which the use of dextran was compared to that of lactated Ringer's solution or to saline as a negative control.

Volume

36

Issue

7

First Page

537

Last Page

539

ISSN

0024-7758

Disciplines

Obstetrics and Gynecology

PubMedID

1719197

Department(s)

Department of Obstetrics and Gynecology

Document Type

Article