Title

Glioblastoma Multiforme in the Muir-Torre Syndrome.

Publication/Presentation Date

6-1-2011

Abstract

Muir-Torre syndrome (MTS) is an autosomal dominant subtype of nonpolyposis colorectal carcinoma (HNPCC) characterized by the development of sebaceous gland tumors and visceral malignancies. The most common subtype of MTS is characterized by germline mutations in mismatch repair (MMR) genes leading to microsatellite instability (MSI). Central nervous system tumors have only rarely been associated with MTS. In this report, we describe the development of a glioblastoma multiforme (GBM) in a patient with MTS. Immunohistochemical analysis of the patient's colon carcinoma and his GBM both revealed loss of the mismatch repair proteins mutS homolog 2 (MSH2) and mutS homolog 6 (MSH6).

Volume

113

Issue

5

First Page

411

Last Page

415

ISSN

1872-6968

Disciplines

Medical Pathology | Pathology

PubMedID

21288634

Peer Reviewed for front end display

Peer-Reviewed

Department(s)

Department of Pathology and Laboratory Medicine

Document Type

Article