Analysis of Collagen Content in the Fetal Wound.

Publication/Presentation Date

10-1-1988

Abstract

The absence of apparent scar formation following the creation of surgical wounds in utero appears to be a phenomenon peculiarly privileged as a sequela of fetal wound healing. Little information exists to explain this disparity from our knowledge of adult wound healing. Therefore, following creation of surgical wounds in fetal rats, at different intervals the healing wounds were harvested and analyzed for collagen content and types. The average proportion of type III collagen was elevated in normal (26.5%) as well as wounded fetal skin (33.8%) when compared with normal levels for the adult (15%). The total collagen content was markedly diminished in the fetal wound. Although embryonal collagen synthesis apparently does exist in fetal reparative processes, the relationship to the lack of gross scarring remains undetermined.

Volume

21

Issue

4

First Page

310

Last Page

315

ISSN

0148-7043

Disciplines

Other Medical Specialties | Surgery

PubMedID

3232919

Department(s)

Department of Surgery, Department of Surgery Faculty

Document Type

Article

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