Type I and Type III Collagen Content of Healing Wounds in Fetal and Adult Rats.
Publication/Presentation Date
4-1-1988
Abstract
Full-thickness, dermal wounds were surgically created on the dorsa of fetal rats on the 17th day of gestation. The granulation tissue which developed after 2 days (19 days of gestation) was harvested from six to nine animals and pooled and the collagen was extracted with 0.5 M acetic acid and acetic acid plus pepsin. The ratio of type III:type I collagen was estimated from densitometer scans of electrophoretically separated alpha-chains. Full-thickness (to fascia depth) wounds were also produced on the dorsa of adult rats and granulation tissue which had developed for different periods of time up to 30 days was excised. Relative proportions of type III and type I collagen were assessed in normal and granulation tissues taken from the adult rats. Both fetal and adult granulation tissues have elevated type III collagen content but normal fetal tissue has a much higher content of type III than does normal adult tissue.
Volume
187
Issue
4
First Page
493
Last Page
497
ISSN
0037-9727
Published In/Presented At
Merkel, J. R., DiPaolo, B. R., Hallock, G. G., & Rice, D. C. (1988). Type I and type III collagen content of healing wounds in fetal and adult rats. Proceedings Of The Society For Experimental Biology And Medicine. Society For Experimental Biology And Medicine (New York, N.Y.), 187(4), 493-497.
Disciplines
Other Medical Specialties | Surgery
PubMedID
3353398
LVHN link
http://search.ebscohost.com/login.aspx?direct=true&db=mnh&AN=3353398&site=ehost-live&scope=site
Department(s)
Department of Surgery, Department of Surgery Faculty
Document Type
Article