Intraoperative 0.05% Chlorhexidine Gluconate Utilization Is Associated With an Increased Incidence of Infection in Hydrophilic Inflatable Penile Prosthesis Surgery: A Multi-Institutional Cohort Study.

Publication/Presentation Date

4-1-2026

Abstract

PURPOSE: Available data are conflicting and limited regarding the antimicrobial effectiveness of 0.05% chlorhexidine gluconate (0.05% CHG) with hydrophilic inflatable penile prostheses (IPP). We used a large multi-institutional cohort to explore the relationship between intraoperative 0.05% CHG use and hydrophilic IPP infection.

MATERIALS AND METHODS: We conducted a retrospective, multi-institutional review of patients who underwent hydrophilic IPP implantation. Consecutive cases involving intraoperative 0.05% CHG as an irrigant and/or dip were compared with a similar number of consecutive control cases without 0.05% CHG. The primary outcome was IPP explant for infection. Predictors of infection were assessed with multivariable logistic regression analysis. Exploratory subgroup analyses further characterized specific 0.05% CHG scenarios.

RESULTS: Among 14 participating institutions, 2150 hydrophilic IPP cases were analyzed. Intraoperative 0.05% CHG was associated with a significantly higher rate of infection compared with using antimicrobials as an irrigant and dip (4.6% vs 2.1%,

CONCLUSIONS: The use of 0.05% CHG with hydrophilic IPP was associated with an elevated infection rate. For hydrophilic IPP surgery, caution with 0.05% CHG use is warranted pending additional prospective evaluation.

Volume

215

Issue

4

First Page

460

Last Page

471

ISSN

1527-3792

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

41264801

Department(s)

Administration and Leadership

Document Type

Article

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