Sex-Specific Differences in Patients with
Publication/Presentation Date
9-9-2024
Abstract
BACKGROUND AND PURPOSE: Understanding sex-based differences in patients with glioblastoma is necessary for accurate personalized treatment planning to improve patient outcomes. Our purpose was to investigate sex-specific differences in molecular, clinical, and radiologic tumor parameters, as well as survival outcomes in patients with glioblastoma, isocitrate dehydrogenase-1 wild-type (
MATERIALS AND METHODS: Retrospective data of 1832 patients with glioblastoma,
RESULTS: Glioblastoma was diagnosed at a median age of 64 years in women compared with 61.9 years in men (false discovery rate [FDR] = 0.003). Men had a higher KPS (above 80) as compared with women (60.4% women versus 69.7% men, FDR = 0.044). Women had lower tumor volumes in enhancing (16.7 cm
CONCLUSIONS: Our study demonstrates significant sex-based differences in clinical and radiologic tumor parameters of patients with glioblastoma. Sex is not an independent prognostic factor for survival outcomes and the tumor parameters influencing patient outcomes are identical for men and women.
Volume
45
Issue
9
First Page
1299
Last Page
1307
ISSN
1936-959X
Published In/Presented At
Gongala, S., Garcia, J. A., Korakavi, N., Patil, N., Akbari, H., Sloan, A., Barnholtz-Sloan, J. S., Sun, J., Griffith, B., Poisson, L. M., Booth, T. C., Jain, R., Mohan, S., Nasralla, M. P., Bakas, S., Tippareddy, C., Puig, J., Palmer, J. D., Shi, W., Colen, R. R., … ReSPOND Consortium (2024). Sex-Specific Differences in Patients with IDH1-Wild-Type Grade 4 Glioma in the ReSPOND Consortium. AJNR. American journal of neuroradiology, 45(9), 1299–1307. https://doi.org/10.3174/ajnr.A8319
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
38684319
Department(s)
Administration and Leadership
Document Type
Article