Ischemic colitis and immunosuppression. An experimental model.
Publication/Presentation Date
2-1-1986
Abstract
The incidence of ischemic colitis in renal transplant recipients approaches 1 percent. The mortality in these patients with ischemic colitis is nearly 70 percent. Immunosuppressive agents have been implicated in the development of ischemic colitis. To study the effect of immunosuppressive agents on ischemic colitis, a 4-cm segment of the colon was devascularized in 27 male Fischer rats. The animals were divided into one control and two treatment groups. One treatment group received methylprednisolone and the other, azathioprine, in doses similar to those of renal transplant recipients. Both experimental groups, either separately or combined, showed significantly greater areas of colonic ischemic changes than did the control group. This study demonstrates that systemic administration of immunosuppressive agents may augment the development of ischemic colitis.
Volume
29
Issue
2
First Page
99
Last Page
101
ISSN
0012-3706
Published In/Presented At
Gomella, L. G., Gehrken, G. A., Hagihara, P. F., & Flanigan, R. C. (1986). Ischemic colitis and immunosuppression. An experimental model. Diseases of the colon and rectum, 29(2), 99–101. https://doi.org/10.1007/BF02555387
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
3510838
Department(s)
Administration and Leadership
Document Type
Article