Development of secondary structure, growth characteristics and cytogenetic analysis of human transitional cell carcinoma xenografts in scid/scid mice.

Authors

• P A McCue
• L G Gomella
• R W Veltri
• G M Marley
• M C Miller
• E C Lattime

Publication/Presentation Date

3-1-1996

Abstract

PURPOSE: The growth of human bladder transitional cell carcinoma (TCC) in scid/scid mice was examined.

MATERIALS AND METHODS: Cystocopically obtained TCC biopsies were implanted in scid/scid mice, and successful xenografts were compared with original tumors for growth and genetic characteristics.

RESULTS: Low grade papillary tumors formed fluid-filled pseudobladders lined with malignant urothelium and papillary fronds containing fibrovascular cores recruited from the murine host. High grade xenografts grew without these secondary structures. When compared with the patient tumors, xenograft growth fractures, as measured by proliferating cell nuclear antigen, p53 expression and ploidy, were similar in each.

CONCLUSIONS: The scid/scid xenografts maintain phenotype and architecture. This model may be useful for studying factors determining tumor grade, angiogenesis and tissue organization.

Volume

155

Issue

3

First Page

1128

Last Page

1132

ISSN

0022-5347

Published In/Presented At

McCue, P. A., Gomella, L. G., Veltri, R. W., Marley, G. M., Miller, M. C., & Lattime, E. C. (1996). Development of secondary structure, growth characteristics and cytogenetic analysis of human transitional cell carcinoma xenografts in scid/scid mice. The Journal of urology, 155(3), 1128–1132.

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

8583578

Department(s)

Administration and Leadership

Document Type

Article