Effects of atriopeptin on particulate guanylate cyclase from rat adrenal.
Publication/Presentation Date
5-30-1985
Abstract
Atriopeptin II activated particulate guanylate cyclase 5-10-fold in a concentration- and time-dependent fashion in crude membranes obtained from homogenates of rat adrenal cortex or medulla. Similar effects were observed with other atriopeptin analogs. Soluble guanylate cyclase and adenylate cyclase in these preparations were not activated. Accumulation of cyclic GMP in minces of adrenal cortex or medulla was increased 6-8-fold due to atriopeptin II activation of particulate guanylate cyclase. Several thiol-reactive agents blocked the activation of particulate guanylate cyclase, suggesting that free thiol groups on membrane proteins may be important in atriopeptin receptor-guanylate cyclase coupling.
Volume
845
Issue
2
First Page
298
Last Page
303
ISSN
0006-3002
Published In/Presented At
Waldman, S. A., Rapoport, R. M., Fiscus, R. R., & Murad, F. (1985). Effects of atriopeptin on particulate guanylate cyclase from rat adrenal. Biochimica et biophysica acta, 845(2), 298–303. https://doi.org/10.1016/0167-4889(85)90191-0
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
2859896
Department(s)
Administration and Leadership
Document Type
Article