Effects of atriopeptins on relaxation and cyclic GMP levels in human coronary artery in vitro.
Publication/Presentation Date
5-13-1986
Abstract
The effects of atriopeptins on relaxation and cyclic GMP levels were examined in human coronary artery. alpha-Atrial natriuretic polypeptide and atriopeptins I, II and III all induced relaxation. Relaxations to atriopeptin I were of a smaller magnitude. The atriopeptins elevated cyclic GMP levels from 2- to 3-fold. These studies suggest that atriopeptins released from the heart may dilate the vasculature of this organ and increase coronary blood flow through the formation of cyclic GMP.
Volume
124
Issue
1-2
First Page
193
Last Page
196
ISSN
0014-2999
Published In/Presented At
Rapoport, R. M., Ginsburg, R., Waldman, S. A., & Murad, F. (1986). Effects of atriopeptins on relaxation and cyclic GMP levels in human coronary artery in vitro. European journal of pharmacology, 124(1-2), 193–196. https://doi.org/10.1016/0014-2999(86)90144-5
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
3013659
Department(s)
Administration and Leadership
Document Type
Article