Modification of infarct material properties limits adverse ventricular remodeling.
BACKGROUND: Infarct expansion after myocardial infarction (MI) is an important phenomenon that initiates and sustains adverse left ventricular (LV) remodeling. We tested the hypothesis that infarct modification by material-induced infarct stiffening and thickening limits infarct expansion and LV remodeling.
METHODS: Anteroapical infarction was induced in 21 sheep. Sheep were randomized to injection of saline (2.6 mL) or tissue filler material (2.6 mL) into the infarct within 3 hours of MI. Animals were monitored for 8 weeks with echocardiography to assess infarct expansion and global LV remodeling. Morphometric measurements were performed of excised hearts to quantify infarct thickness. Regional blood flow was assessed with colored microspheres. Infarct material properties were measured using biaxial tensile testing.
RESULTS: Compared with controls at 8 weeks, treatment animals had less infarct expansion, reduced LV dilatation (LV systolic volumes: 60.8±4.3 vs 80.3±6.9 mL; p
CONCLUSIONS: Durable infarct thickening and stiffening can be achieved by infarct biomaterial injection, resulting in the amelioration of infarct expansion and global LV remodeling. Further material optimization will allow for clinical translation of this novel treatment paradigm.
Published In/Presented At
Morita, M., Eckert, C. E., Matsuzaki, K., Noma, M., Ryan, L. P., Burdick, J. A., Jackson, B. M., Gorman, J. H., 3rd, Sacks, M. S., & Gorman, R. C. (2011). Modification of infarct material properties limits adverse ventricular remodeling. The Annals of thoracic surgery, 92(2), 617–624. https://doi.org/10.1016/j.athoracsur.2011.04.051
Medicine and Health Sciences
Department of Medicine, Cardiology Division