Neuron-Specific Glycine Metabolism Links Transfer RNA Epitranscriptomic Regulation to Complex Behaviors.

Authors

• Jennifer Blaze
• Viviana Dolores Evans
• Jessica Abigail Feria Pliego
• Petr Unichenko
• Behnam Javidfar
• Soeren Heissel
• Hanan Alwaseem
• Zachary Pennington
• Denise Cai
• Henrik Molina
• Christian Henneberger
• Schahram Akbarian

Publication/Presentation Date

3-1-2025

Abstract

BACKGROUND: The presence of treatment resistance in neuropsychiatric disease suggests that novel mechanism-based discoveries and therapies could benefit the field, with a viable candidate being transfer RNA (tRNA) epitranscriptomics.

METHODS: To link specific molecular alterations resulting from neuronal

RESULTS: Increased motivated escape behaviors were specifically observed in mice with neuron-specific ablation of

CONCLUSIONS: Alterations in neuronal glycine metabolism, resulting from targeted ablation of the glycine cleavage system or disruption of the tRNA regulome, elicit changes in complex behaviors in mice relevant for neuropsychiatric phenotypes.

Volume

5

Issue

2

First Page

100432

Last Page

100432

ISSN

2667-1743

Published In/Presented At

Blaze, J., Evans, V. D., Feria Pliego, J. A., Unichenko, P., Javidfar, B., Heissel, S., Alwaseem, H., Pennington, Z., Cai, D., Molina, H., Henneberger, C., & Akbarian, S. (2024). Neuron-Specific Glycine Metabolism Links Transfer RNA Epitranscriptomic Regulation to Complex Behaviors. Biological psychiatry global open science, 5(2), 100432. https://doi.org/10.1016/j.bpsgos.2024.100432

Disciplines

Medicine and Health Sciences

PubMedID

39911537

Department(s)

Medical Education

Document Type

Article