Molecular diagnostics in periprosthetic joint infection.
Publication/Presentation Date
9-1-2011
Abstract
Periprosthetic joint infection (PJI) is a significant and costly challenge to the orthopedic community. The lack of a gold standard for diagnosis remains the biggest obstacle in the detection and subsequent treatment of PJI. Molecular markers in the serum and joint fluid aspirate hold immense promise to enhance the development of a firm diagnostic criterion. The primary goal is one marker with high sensitivity and specificity. Here, we review our current research efforts in the field of molecular markers: C-reactive protein, erythrocyte sedimentation rate, white blood cells, and leukocyte esterase. Each marker has been studied to determine its sensitivity, specificity, and positive and negative predictive values in diagnosing PJI.
Volume
34
Issue
9
First Page
847
Last Page
855
ISSN
1724-6040
Published In/Presented At
Parvizi, J., Walinchus, L., & Adeli, B. (2011). Molecular diagnostics in periprosthetic joint infection. The International journal of artificial organs, 34(9), 847–855. https://doi.org/10.5301/ijao.5000054
Disciplines
Medicine and Health Sciences
PubMedID
22094565
Department(s)
Department of Emergency Medicine
Document Type
Article