Analysis of acute naproxen administration on memory in young adults: A randomized, double-blind, placebo-controlled study.

Authors

Jack H Wilson
Amy H Criss
Sean A Spangler
Katherine Walukevich
Sandra Hewett

Publication/Presentation Date

10-1-2017

Abstract

Nonsteroidal anti-inflammatory drugs work by non-selectively inhibiting cyclooxygenase enzymes. Evidence indicates that metabolites of the cyclooxygenase pathway play a critical role in the process of learning and memory. We evaluated whether acute naproxen treatment impairs short-term working memory, episodic memory, or semantic memory in a young, healthy adult population. Participants received a single dose of placebo or naproxen (750 mg) in random order separated by 7-10 days. Two hours following administration, participants completed five memory tasks. The administration of acute high-dose naproxen had no effect on memory in healthy young adults.

Volume

31

Issue

10

First Page

1374

Last Page

1376

ISSN

1461-7285

Published In/Presented At

Wilson, J. H., Criss, A. H., Spangler, S. A., Walukevich, K., & Hewett, S. (2017). Analysis of acute naproxen administration on memory in young adults: A randomized, double-blind, placebo-controlled study. Journal of psychopharmacology (Oxford, England), 31(10), 1374–1376. https://doi.org/10.1177/0269881117724406

Disciplines

Medicine and Health Sciences

PubMedID

28879792

Department(s)

Fellows and Residents

Document Type

Article