Glycan repositioning of influenza hemagglutinin stem facilitates the elicitation of protective cross-group antibody responses.
Publication/Presentation Date
2-7-2020
Abstract
The conserved hemagglutinin (HA) stem has been a focus of universal influenza vaccine efforts. Influenza A group 1 HA stem-nanoparticles have been demonstrated to confer heterosubtypic protection in animals; however, the protection does not extend to group 2 viruses, due in part to differences in glycosylation between group 1 and 2 stems. Here, we show that introducing the group 2 glycan at Asn38
Volume
11
Issue
1
First Page
791
Last Page
791
ISSN
2041-1723
Published In/Presented At
Boyoglu-Barnum, S., Hutchinson, G. B., Boyington, J. C., Moin, S. M., Gillespie, R. A., Tsybovsky, Y., Stephens, T., Vaile, J. R., Lederhofer, J., Corbett, K. S., Fisher, B. E., Yassine, H. M., Andrews, S. F., Crank, M. C., McDermott, A. B., Mascola, J. R., Graham, B. S., & Kanekiyo, M. (2020). Glycan repositioning of influenza hemagglutinin stem facilitates the elicitation of protective cross-group antibody responses. Nature communications, 11(1), 791. https://doi.org/10.1038/s41467-020-14579-4
Disciplines
Medicine and Health Sciences
PubMedID
32034141
Department(s)
Fellows and Residents
Document Type
Article