Prevalence and Impact of Chronic Kidney Disease on Outcomes and Recurrence of Takotsubo Syndrome - A Comprehensive Review.

Publication/Presentation Date

5-22-2025

Abstract

Takotsubo Syndrome (TTS) is a condition that usually affects the left ventricle (LV), primarily in the apical region characterized by transient left ventricular dysfunction triggered by a variety of stresses. Patients with TTS often present clinically as acute coronary syndrome (ACS) making the diagnosis challenging. TTS can lead to serious adverse events, such as cardiac arrhythmias, cardiogenic shock, and thromboembolic events, which can worsen an already poor prognosis. Chronic kidney disease (CKD) is a well-established risk factor for cardiovascular disease, and TTS prognosis is worsened when kidney function is compromised. With a prevalence of 6.7% among TTS patients, CKD increases the morbidity and mortality risks in TTS patients. Moreover, CKD exacerbates TTS recurrence, with risk factors including female sex, advanced age, and diabetes mellitus. Clinical management of TTS in CKD patients requires comprehensive evaluation and tailored interventions. While ACE inhibitors and angiotensin receptor blockers may mitigate recurrence risk, optimization of dialysis treatments and management of comorbidities are paramount.This review synthesizes current literature to elucidate the prevalence, recurrence, pathophysiological mechanisms, clinical implications, and management strategies of CKD in TTS patients.

ISSN

1538-2990

Disciplines

Medicine and Health Sciences

PubMedID

40412618

Department(s)

Fellows and Residents

Document Type

Article

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