Transcatheter Aortic Valve Implantation in Cardiac Amyloidosis and Aortic Stenosis.
Publication/Presentation Date
7-1-2023
Abstract
Aortic stenosis (AS) and cardiac amyloidosis (CA) occur concomitantly in a significant number of patients and portend a higher risk of all-cause mortality. Previous studies have investigated outcomes in patients with concomitant CA/AS who underwent transcatheter aortic valve implantation (TAVI) versus medical therapy alone, but no evidence-based consensus regarding the ideal management of these patients has been established. Medline, Scopus, and Cochrane Central Register of Controlled Trials were systematically searched to identify relevant studies. Methodologic bias was assessed using the modified Newcastle-Ottawa scale for observational studies. A total of 4 observational studies comprising 83 patients were included. Of these, 45 patients (54%) underwent TAVI, whereas 38 (46%) were managed conservatively. Of the 3 studies that included baseline characteristics by treatment group, 30% were women. The risk of all-cause mortality was found to be significantly lower in patients who underwent TAVI than those treated with conservative medical therapy alone (odds ratio 0.24, 95% confidence interval 0.08 to 0.73). In conclusion, this meta-analysis suggests a lower risk of all-cause mortality in patients with CA with AS who underwent TAVI than those managed with medical therapy alone.
Volume
198
First Page
101
Last Page
107
ISSN
1879-1913
Published In/Presented At
Riley, J. M., Junarta, J., Ullah, W., Siddiqui, M. U., Anzelmi, A., Ruge, M., Vishnevsky, A., Alvarez, R. J., Ruggiero, N. J., Rajapreyar, I. N., & Brailovsky, Y. (2023). Transcatheter Aortic Valve Implantation in Cardiac Amyloidosis and Aortic Stenosis. The American journal of cardiology, 198, 101–107. https://doi.org/10.1016/j.amjcard.2023.04.003
Disciplines
Medicine and Health Sciences
PubMedID
37183091
Department(s)
Fellows and Residents
Document Type
Article