Gender disparities in outcomes of cardiogenic shock secondary to Takotsubo cardiomyopathy.
Publication/Presentation Date
10-1-2024
Abstract
BACKGROUND: Takotsubo cardiomyopathy (TTC) has a preponderance for females, particularly postmenopausal. However, recent data from multicenter registries identified a worse prognosis in male patients, particularly with cardiogenic shock. We aim to investigate gender disparities in outcomes of TTC-associated cardiogenic shock (TTC-CS).
METHODS: The National Readmission Database (2016-2020) was utilized to identify TTC-CS hospitalizations. Cohorts were stratified by gender. A Propensity Score Matching (PSM) model, which utilized complete Mahalanobis Distance Matching within the Propensity Score Caliper following multivariate regression, successfully matched males and females. Pearson's χ
RESULTS: Among 12,803 TTC-CS hospitalizations, the majority (74.1 %) were females (N: 9490), and 25.9 % were males (N: 3313). On propensity-matched cohorts (2609), males were found to have higher in-hospital mortality (31 % vs. 26 %,
CONCLUSION: For TTC-CS hospitalization, males have higher in-hospital mortality and complication rates, along with higher LOS and cost of hospitalization. Despite advances in the management of CS, there was no significant difference in mortality from 2016 to 2020.
Volume
46
First Page
100453
Last Page
100453
ISSN
2666-6022
Published In/Presented At
Ali, S., Khlidj, Y., Kumar, M., Kumar, S., Duhan, S., Farooq, F., Keisham, B., Ponna, P. K., & Modi, K. (2024). Gender disparities in outcomes of cardiogenic shock secondary to Takotsubo cardiomyopathy. American heart journal plus : cardiology research and practice, 46, 100453. https://doi.org/10.1016/j.ahjo.2024.100453
Disciplines
Medicine and Health Sciences
PubMedID
39319103
Department(s)
Fellows and Residents
Document Type
Article