Atorvastatin-Induced Liver Injury With Concurrent Rhabdomyolysis After a Positive Rechallenge.
Publication/Presentation Date
1-1-2025
Abstract
Statin-induced liver injury has been widely described. However, cases of clinically significant liver injury are rare. We present a 56-year-old woman who developed atorvastatin-induced grade III acute liver injury with concurrent rhabdomyolysis that worsened after rechallenging, which highlighted the need for pharmacovigilance with statins. The Roussel Uclaf Causality Assessment Method and Revised Electronic Causality Assessment Method both showed that atorvastatin was highly probable in causing hepatotoxicity. To our knowledge, this is the first reported case of concurrent drug-induced liver injury and rhabdomyolysis after a positive rechallenge with atorvastatin.
Volume
12
Issue
1
First Page
01570
Last Page
01570
ISSN
2326-3253
Published In/Presented At
Singh, H., Khalaf, A., Kunkle, B. F., Gholami, S., Lewis, J. H., & Rangnekar, A. S. (2024). Atorvastatin-Induced Liver Injury With Concurrent Rhabdomyolysis After a Positive Rechallenge. ACG case reports journal, 12(1), e01570. https://doi.org/10.14309/crj.0000000000001570
Disciplines
Medicine and Health Sciences
PubMedID
39742213
Department(s)
Fellows and Residents
Document Type
Article