Dynamical system modeling to simulate donor T cell response to whole exome sequencing-derived recipient peptides: Understanding randomness in alloreactivity incidence following stem cell transplantation.
Quantitative relationship between the magnitude of variation in minor histocompatibility antigens (mHA) and graft versus host disease (GVHD) pathophysiology in stem cell transplant (SCT) donor-recipient pairs (DRP) is not established. In order to elucidate this relationship, whole exome sequencing (WES) was performed on 27 HLA matched related (MRD), & 50 unrelated donors (URD), to identify nonsynonymous single nucleotide polymorphisms (SNPs). An average 2,463 SNPs were identified in MRD, and 4,287 in URD DRP (p
Published In/Presented At
Koparde, V., Abdul Razzaq, B., Suntum, T., Sabo, R., Scalora, A., Serrano, M., Jameson-Lee, M., Hall, C., Kobulnicky, D., Sheth, N., Feltz, J., Contaifer, D., Jr, Wijesinghe, D., Reed, J., Roberts, C., Qayyum, R., Buck, G., Neale, M., & Toor, A. (2017). Dynamical system modeling to simulate donor T cell response to whole exome sequencing-derived recipient peptides: Understanding randomness in alloreactivity incidence following stem cell transplantation. PloS one, 12(12), e0187771. https://doi.org/10.1371/journal.pone.0187771
Medicine and Health Sciences
Department of Medicine, Hematology-Medical Oncology Division