Dynamical system modeling to simulate donor T cell response to whole exome sequencing-derived recipient peptides: Understanding randomness in alloreactivity incidence following stem cell transplantation.
Publication/Presentation Date
1-1-2017
Abstract
Quantitative relationship between the magnitude of variation in minor histocompatibility antigens (mHA) and graft versus host disease (GVHD) pathophysiology in stem cell transplant (SCT) donor-recipient pairs (DRP) is not established. In order to elucidate this relationship, whole exome sequencing (WES) was performed on 27 HLA matched related (MRD), & 50 unrelated donors (URD), to identify nonsynonymous single nucleotide polymorphisms (SNPs). An average 2,463 SNPs were identified in MRD, and 4,287 in URD DRP (p
Volume
12
Issue
12
First Page
0187771
Last Page
0187771
ISSN
1932-6203
Published In/Presented At
Koparde, V., Abdul Razzaq, B., Suntum, T., Sabo, R., Scalora, A., Serrano, M., Jameson-Lee, M., Hall, C., Kobulnicky, D., Sheth, N., Feltz, J., Contaifer, D., Jr, Wijesinghe, D., Reed, J., Roberts, C., Qayyum, R., Buck, G., Neale, M., & Toor, A. (2017). Dynamical system modeling to simulate donor T cell response to whole exome sequencing-derived recipient peptides: Understanding randomness in alloreactivity incidence following stem cell transplantation. PloS one, 12(12), e0187771. https://doi.org/10.1371/journal.pone.0187771
Disciplines
Medicine and Health Sciences
PubMedID
29194460
Department(s)
Department of Medicine, Hematology-Medical Oncology Division
Document Type
Article