A dynamical systems perspective on chimeric antigen receptor T-cell dosing.
Chimeric antigen receptor T cells (CAR T cells) are dosed similarly to donor lymphocyte infusions following hematopoietic cell transplantation. However, the mechanism driving proliferation in CAR T cells is distinct from conventional T cells. As such there are quantitative differences in the antigen response of these engineered cells when compared with conventional T cells. In this perspective paper the logistic equation of growth is used to develop a mathematical basis for understanding the difference between CAR T cell and conventional T cell response to antigen burden.
Published In/Presented At
Toor, A. A., Chesney, A., Zweit, J., Reed, J., & Hashmi, S. K. (2019). A dynamical systems perspective on chimeric antigen receptor T-cell dosing. Bone marrow transplantation, 54(3), 485–489. https://doi.org/10.1038/s41409-018-0329-8
Medicine and Health Sciences
Department of Medicine, Hematology-Medical Oncology Division