OBJECTIVES: The authors sought to investigate the association between P2Y
BACKGROUND: The association between platelet reactivity on clopidogrel and the risk for ischemic cerebrovascular events remains unclear.
METHODS: Incidence, predictors, and prognostic impact of IS were evaluated among patients enrolled in the multicenter, prospective ADAPT-DES (Assessment of Dual AntiPlatelet Therapy With Drug Eluting Stents) study. By protocol, patients were maintained on aspirin for 2 years and clopidogrel for at least 1 year. Baseline platelet reactivity on clopidogrel and aspirin were assessed by means of VerifyNow point-of-care assay after successful DES implantation.
RESULTS: Among 8,582 patients enrolled, 68 (0.8%) had an IS during 2-year follow-up. Across the spectrum of PRU, rates of IS were progressively greater as patients transitioned from the lowest quintile of PRU (more P2Y
CONCLUSIONS: Higher PRU was associated with increased risk of IS after coronary DES implantation. Ensuring adequate platelet P2Y
Published In/Presented At
Giustino, G., Redfors, B., Kirtane, A. J., Mehran, R., Dangas, G. D., Witzenbichler, B., Neumann, F. J., Weisz, G., Généreux, P., Maehara, A., McAndrew, T., Farhan, S., Rinaldi, M. J., Metzger, D. C., Henry, T. D., Cox, D. A., Duffy, P. L., Mazzaferri, E. L., Jr, Brodie, B. R., Stuckey, T. D., … Stone, G. W. (2018). Platelet Reactivity and Risk of Ischemic Stroke After Coronary Drug-Eluting Stent Implantation: From the ADAPT-DES Study. JACC. Cardiovascular interventions, 11(13), 1277–1286. https://doi.org/10.1016/j.jcin.2018.01.263
Department of Medicine