Role of cardiac MRI and nuclear imaging in cardiac resynchronization therapy.
Publication/Presentation Date
12-1-2009
Abstract
Cardiac resynchronization has emerged as a highly effective therapy for heart failure. However, up to 40% of patients do not benefit from this treatment. In this Review, we discuss the potential role of MRI and nuclear molecular imaging in providing additional insights into the response to cardiac resynchronization therapy. Variables with potential prognostic and therapeutic values include the evaluation of cardiac dyssynchrony, scar, cardiac sympathetic function, myocardial blood flow, myocardial glucose and oxidative metabolism. Other molecular targets to characterize apoptosis, fatty acid metabolism, angiogenesis and angiotensin-converting enzyme activity will also be described. The potential use of these techniques in identifying and measuring responses to cardiac resynchronization therapy and future areas of research will be explored.
Volume
6
Issue
12
First Page
759
Last Page
770
ISSN
1759-5010
Published In/Presented At
Aggarwal, N. R., Martinez, M. W., Gersh, B. J., & Chareonthaitawee, P. (2009). Role of cardiac MRI and nuclear imaging in cardiac resynchronization therapy. Nature reviews. Cardiology, 6(12), 759–770. https://doi.org/10.1038/nrcardio.2009.189
Disciplines
Medicine and Health Sciences
PubMedID
19884903
Department(s)
Department of Medicine
Document Type
Article