Monoclonal antibody B72.3 as a diagnostic adjunct in fine needle aspirates of breast masses.
Fine needle aspirations of breast masses were evaluated to establish a cytologic diagnosis. In 45 cases, the sensitivity was 73%, specificity 100%, and diagnostic accuracy 84%. Fifty cases (27 malignant and 23 benign) were evaluated by immunoperoxidase staining of the needle aspirates, using the monoclonal antibody B72.3. Twenty-six of 27 malignant cases stained positively, and 22 of 23 benign cases were negative. The sensitivity was 96%, specificity was 96%, and diagnostic accuracy was 96%. All cases considered malignant cytologically were confirmed by immunocytochemistry. In addition, the B72.3 monoclonal antibody appears to be a valuable diagnostic adjunct in atypical and suspicious cases, particularly those in which hypocellularity and/or cellular monomorphism preclude a diagnosis of malignancy by routine cytologic examination.
Published In/Presented At
Lundy, J., Lozowski, M., & Mishriki, Y. (1986). Monoclonal antibody B72.3 as a diagnostic adjunct in fine needle aspirates of breast masses. Annals of surgery, 203(4), 399–402. https://doi.org/10.1097/00000658-198604000-00010
Medicine and Health Sciences
Department of Medicine