Circulating angiogenic factors in singleton vs multiple-gestation pregnancies.
OBJECTIVE: Placental soluble fms-like tyrosine kinase-1 may contribute to the pathogenesis of preeclampsia. Here we describe alterations in serum angiogenic factor levels in women with multiple gestation pregnancies, a major preeclampsia risk factor.
STUDY DESIGN: We collected serial serum specimens from 101 pregnant women at high preeclampsia risk between 22 and 36 weeks' gestation. Soluble fms-like tyrosine kinase-1 and placental growth factor were measured by enzyme-linked immunosorbent assay. Women who had preeclampsia or gestational hypertension develop were excluded.
RESULTS: Maternal soluble fms-like tyrosine kinase-1 was higher in multiple gestation (n = 20) compared with high-risk singleton (n = 81) pregnancies for each gestational age range examined. Maternal placental growth factor was significantly higher in multiple vs high-risk singletons before 31 weeks' gestation, whereas the soluble fms-like tyrosine kinase-1/placental growth factor ratio was higher in multiple vs high-risk singletons after 27 weeks.
CONCLUSION: Alterations in circulating angiogenic factors are present in women with multiple gestations and may contribute to higher preeclampsia risk in this population.
Published In/Presented At
Maynard, S. E., Moore Simas, T. A., Solitro, M. J., Rajan, A., Crawford, S., Soderland, P., & Meyer, B. A. (2008). Circulating angiogenic factors in singleton vs multiple-gestation pregnancies. American journal of obstetrics and gynecology, 198(2), 200.e1–200.e2007. https://doi.org/10.1016/j.ajog.2007.08.042
Medicine and Health Sciences
Department of Medicine