The biology of 5-lipoxygenase: function, structure, and regulatory mechanisms.
Publication/Presentation Date
1-1-1999
Abstract
5-Lipoxygenase (5-LO) catalyzes the two-step conversion of arachidonic acid to leukotriene A4 (LTA4). The first step consists of the oxidation of arachidonic acid to the unstable intermediate 5-hydroperoxyeicosatetraenoic acid (5-HPETE), and the second step is the dehydration of 5-HPETE to form LTA4. These events are the first committed reactions leading to the synthesis of all leukotrienes and play a critical role in controlling leukotriene production. 5-LO has evolved many complex structural features and regulatory mechanisms to allow it to fulfill this highly specialized role. The biology of 5-LO is reviewed here with an emphasis on enzymatic function, protein and gene structure, essential cofactors, and the many regulatory mechanisms controlling its expression.
Volume
111
Issue
6
First Page
525
Last Page
536
ISSN
1081-650X
Published In/Presented At
Silverman, E. S., & Drazen, J. M. (1999). The biology of 5-lipoxygenase: function, structure, and regulatory mechanisms. Proceedings of the Association of American Physicians, 111(6), 525–536. https://doi.org/10.1046/j.1525-1381.1999.t01-1-99231.x
Disciplines
Medicine and Health Sciences
PubMedID
10591081
Department(s)
Department of Medicine
Document Type
Article