1,25-Dihydroxyvitamin D-Mediated Hypercalcemia in a Patient With Maligancy Without Lymphoma
Introduction: Hypercalcemia resulting from calcium homeostasis imbalance is seen in one-third of malignancies. Solid malignancies cause hypercalcemia from high parathyroid hormone-related peptide (PTHrP) and, infrequently, from osteolytic cytokines. Excessive 1, 25-dihydroxyvitamin D, seen mostly in lymphoma, causes hypercalcemia by 1-alpha-hydroxylation of 25-hydroxyvitamin D. This mechanism has also been reported in a few cases of dysgerminoma, myofibroblastic tumors, and gastrointestinal stromal tumors.
Case Report: We present an unusual case of 1,25-dihydroxyvitamin D mediated hypercalcemia in a 62-year-old male with colonic adenocarcinoma and mesothelioma.
Conclusion: This case emphasizes that elevated 1,25-dihydroxyvitamin D may be a hypercalcemia etiology in non-lymphoma malignancies and should to be considered when workup for elevated PTHrP and osteolytic hypercalcemia is negative.
Published In/Presented At
Mastoris, K., Park, S., Magaji, V. (2015). 1,25- Dihydroxyvitamin D-Mediated Hypercalcemia in a Patient with Malignancy Without Lymphoma. International Journal of Case Reports and Images,6(7), 403-406. Retrieved from http://www.ijcasereportsandimages.com
Medical Sciences | Medicine and Health Sciences
Peer Reviewed for front end display
Department of Medicine, Department of Medicine Faculty, Department of Medicine Fellows and Residents