The Changing Landscape for Stroke Prevention in AF: Findings From the GLORIA-AF Registry Phase 2.
Publication/Presentation Date
2-21-2017
Abstract
BACKGROUND: GLORIA-AF (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation) is a prospective, global registry program describing antithrombotic treatment patterns in patients with newly diagnosed nonvalvular atrial fibrillation at risk of stroke. Phase 2 began when dabigatran, the first non-vitamin K antagonist oral anticoagulant (NOAC), became available.
OBJECTIVES: This study sought to describe phase 2 baseline data and compare these with the pre-NOAC era collected during phase 1.
METHODS: During phase 2, 15,641 consenting patients were enrolled (November 2011 to December 2014); 15,092 were eligible. This pre-specified cross-sectional analysis describes eligible patients' baseline characteristics. Atrial fibrillation disease characteristics, medical outcomes, and concomitant diseases and medications were collected. Data were analyzed using descriptive statistics.
RESULTS: Of the total patients, 45.5% were female; median age was 71 (interquartile range: 64, 78) years. Patients were from Europe (47.1%), North America (22.5%), Asia (20.3%), Latin America (6.0%), and the Middle East/Africa (4.0%). Most had high stroke risk (CHA
CONCLUSIONS: The baseline data from GLORIA-AF phase 2 demonstrate that in newly diagnosed nonvalvular atrial fibrillation patients, NOAC have been highly adopted into practice, becoming more frequently prescribed than VKA in Europe and North America. Worldwide, however, a large proportion of patients remain undertreated, particularly in Asia and North America. (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients With Atrial Fibrillation [GLORIA-AF]; NCT01468701).
Volume
69
Issue
7
First Page
777
Last Page
785
ISSN
1558-3597
Published In/Presented At
Huisman, M. V., Rothman, K. J., Paquette, M., Teutsch, C., Diener, H. C., Dubner, S. J., Halperin, J. L., Ma, C. S., Zint, K., Elsaesser, A., Bartels, D. B., Lip, G. Y., & GLORIA-AF Investigators (2017). The Changing Landscape for Stroke Prevention in AF: Findings From the GLORIA-AF Registry Phase 2. Journal of the American College of Cardiology, 69(7), 777–785. https://doi.org/10.1016/j.jacc.2016.11.061
Disciplines
Medicine and Health Sciences
PubMedID
28209218
Department(s)
Department of Medicine
Document Type
Article