The Concentration of Total Nucleated Cells in Harvested Bone Marrow for Transplantation Has Decreased over Time.
Publication/Presentation Date
7-1-2019
Abstract
Bone marrow (BM) is an essential source of hematopoietic stem cell grafts for many allogeneic hematopoietic cell transplant (HCT) recipients, including adult patients (for specific diseases and transplantation strategies) and the majority of pediatric recipient. However, since the advent of granulocyte colony-stimulating factor-mobilized peripheral blood stem cell (PBSC) grafts, there has been a significant decrease in the use of BM in HCT, thought to be due mainly to the increased logistical challenges in harvesting BM compared with PBSCs, as well as generally no significant survival advantage of BM over PBSCs. The decreased frequency of collection has the potential to impact the quality of BM harvests. In this study, we examined >15,000 BM donations collected at National Marrow Donor Program centers between 1994 and 2016 and found a significant decline in the quality of BM products, as defined by the concentration of total nucleated cells (TNCs). The mean TNC concentration in BM donations dropped from 21.8 × 10
Volume
25
Issue
7
First Page
1325
Last Page
1330
ISSN
1523-6536
Published In/Presented At
Prokopishyn, N. L., Logan, B. R., Kiefer, D. M., Sees, J. A., Chitphakdithai, P., Ahmed, I. A., Anderlini, P. N., Beitinjaneh, A. M., Bredeson, C., Cerny, J., Chhabra, S., Daly, A., Diaz, M. A., Farhadfar, N., Frangoul, H. A., Ganguly, S., Gastineau, D. A., Gergis, U., Hale, G. A., Hematti, P., … Shaw, B. E. (2019). The Concentration of Total Nucleated Cells in Harvested Bone Marrow for Transplantation Has Decreased over Time. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 25(7), 1325–1330. https://doi.org/10.1016/j.bbmt.2019.01.034
Disciplines
Medicine and Health Sciences
PubMedID
30716454
Department(s)
Department of Medicine, Hematology-Medical Oncology Division, Lehigh Valley Topper Cancer Institute
Document Type
Article