Celecoxib-induced cholestatic liver failure requiring orthotopic liver transplantation.
Publication/Presentation Date
8-21-2009
Abstract
Selective cyclooxygenase-2 (COX-2) inhibitors are widely used due to their efficacy and good safety profile. However, recent case reports have described varying degrees of liver injuries associated with the use of COX-2 inhibitors. We report the case of a patient who developed acute cholestatic hepatitis progressing to hepatic failure requiring liver transplantation, following a 3-d course of celecoxib for treatment of generalized muscle aches and pains. The clinical presentation, the laboratory data, as well as the liver histopathology were supportive of the putative diagnosis of drug induced liver injury.
Volume
15
Issue
31
First Page
3937
Last Page
3939
ISSN
2219-2840
Published In/Presented At
El Hajj, I. I., Malik, S. M., Alwakeel, H. R., Shaikh, O. S., Sasatomi, E., & Kandil, H. M. (2009). Celecoxib-induced cholestatic liver failure requiring orthotopic liver transplantation. World journal of gastroenterology, 15(31), 3937–3939. https://doi.org/10.3748/wjg.15.3937
Disciplines
Medicine and Health Sciences
PubMedID
19701976
Department(s)
Department of Medicine
Document Type
Article