Nephrotoxicity of amphotericin B in the treatment of cryptococcal meningitis in acquired immunodeficiency syndrome patients.
Publication/Presentation Date
9-1-2009
Abstract
OBJECTIVES: To describe the incidence of renal dysfunction, hypokalaemia and hypomagnesaemia in AIDS patients with cryptococcal meningitis and on amphotericin B treatment. Secondary objective was to determine all-cause mortality in the same group.
DESIGN: Prospective, observational study.
SETTING: Kenyatta National Hospital (KNH), Nairobi, Kenya.
SUBJECTS: Seventy consecutive patients with AIDS and cryptococcal meningitis on amphotericin B.
RESULTS: About 58.6% of the patients had at least 100% rise in the creatinine level. Thirty eight point six per cent of patients experienced a rise in serum creatinine of at least 50%. Ninty three per cent of the patients developed hypokalaemia and 80% had hypomagnesaemia at trough magnesium level. Only 54.3% of patients completed the intended 14-day treatment. Thirty point five per cent of patients died within the two week follow-up period.
CONCLUSION: The incidences of amphotericin B associated nephrotoxicity, hypokalemia and hypomagnesaemia were high in this studied population.
Volume
86
Issue
9
First Page
435
Last Page
441
ISSN
0012-835X
Published In/Presented At
Ochieng, P. O., McLigeyo, S. O., Amayo, E. O., Kayima, J. K., & Omonge, E. O. (2009). Nephrotoxicity of amphotericin B in the treatment of cryptococcal meningitis in acquired immunodeficiency syndrome patients. East African medical journal, 86(9), 435–441. https://doi.org/10.4314/eamj.v86i9.54166
Disciplines
Medicine and Health Sciences
PubMedID
21644414
Department(s)
Department of Medicine
Document Type
Article