Susceptibility locus for Alzheimer's disease on chromosome 10.
Publication/Presentation Date
12-22-2000
Abstract
The apolipoprotein E (APOE) gene is the only genetic risk factor that has so far been linked to risk for late-onset Alzheimer's disease (LOAD). However, 50 percent of Alzheimer's disease cases do not carry an APOE4 allele, suggesting that other risk factors must exist. We performed a two-stage genome-wide screen in sibling pairs with LOAD to detect other susceptibility loci. Here we report evidence for an Alzheimer's disease locus on chromosome 10. Our stage one multipoint lod score (logarithm of the odds ratio for linkage/no linkage) of 2.48 (266 sibling pairs) increased to 3.83 in stage 2 (429 sibling pairs) close to D10S1225 (79 centimorgans). This locus modifies risk for Alzheimer's disease independent of APOE genotype.
Volume
290
Issue
5500
First Page
2304
Last Page
2305
ISSN
0036-8075
Published In/Presented At
Myers, A., Holmans, P., Marshall, H., Kwon, J., Meyer, D., Ramic, D., Shears, S., Booth, J., DeVrieze, F. W., Crook, R., Hamshere, M., Abraham, R., Tunstall, N., Rice, F., Carty, S., Lillystone, S., Kehoe, P., Rudrasingham, V., Jones, L., Lovestone, S., … Goate, A. M. (2000). Susceptibility locus for Alzheimer's disease on chromosome 10. Science (New York, N.Y.), 290(5500), 2304–2305. https://doi.org/10.1126/science.290.5500.2304
Disciplines
Medicine and Health Sciences
PubMedID
11125144
Department(s)
Department of Medicine, Cardiology Division
Document Type
Article