Distinct type 1 immune networks underlie the severity of restrictive lung disease after COVID-19.

Publication/Presentation Date

4-1-2025

Abstract

The variable origins of persistent breathlessness after coronavirus disease 2019 (COVID-19) have hindered efforts to decipher the immunopathology of lung sequelae. Here we analyzed hundreds of cellular and molecular features in the context of discrete pulmonary phenotypes to define the systemic immune landscape of post-COVID lung disease. Cluster analysis of lung physiology measures highlighted two phenotypes of restrictive lung disease that differed according to their impaired diffusion and severity of fibrosis. Machine learning revealed marked CCR5

Volume

26

Issue

4

First Page

595

Last Page

606

ISSN

1529-2916

Disciplines

Medicine and Health Sciences

PubMedID

40140496

Department(s)

Department of Medicine

Document Type

Article

Share

COinS