Efficacy and safety of empagliflozin in acute heart failure: a systematic review and meta-analysis.

Publication/Presentation Date

5-5-2025

Abstract

BACKGROUND: Acute heart failure (AHF) is leading cause of hospitalization and mortality. Empagliflozin, a Sodium Glucose Co-transporter 2 inhibitor (SGLT-2i), has demonstrated benefits in HFrEF and HFpEF, but its role in AHF remains under-explored.

OBJECTIVE: Assess safety and efficacy of empagliflozin in AHF.

METHODS: A systematic review and meta-analysis adhering to PRISMA 2020 guidelines was conducted. A search on 25 February 2025, identified Phase IIb and III randomized controlled trials (RCTs) involving adults with AHF from databases like Medline®, Cochrane CENTRAL, Embase, and ClinicalTrials.gov. Outcomes included all-cause mortality, HF rehospitalization, cardiovascular deaths, and serious adverse events. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using a random-effects model. Heterogeneity was assessed with I2 and Cochrane Q-statistic.

RESULTS: Three RCTs (

CONCLUSION: Empagliflozin reduces mortality in AHF with a favorable safety profile, highlighting need for further trials.

First Page

1

Last Page

7

ISSN

1744-8298

Disciplines

Medicine and Health Sciences

PubMedID

40324865

Department(s)

Department of Medicine, Cardiology Division

Document Type

Article

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