Efficacy of Total-Body Irradiation-based Intensified Myeloablative Regimens for Acute Leukemia-An International Collaborative Study.
Publication/Presentation Date
6-1-2025
Abstract
BACKGROUND: In this study, we compared outcomes of intensified myeloablative conditioning regimens using large registry data from Japan (Japanese Society for Transplantation and Cellular Therapy) and the United States (Center for International Blood and Marrow Transplant Research).
METHODS: Adult patients who underwent their first myeloablative allogeneic hematopoietic stem cell transplantation (HSCT) for acute leukemia in remission between 2010 and 2018 using conditioning regimens of cyclophosphamide plus total-body irradiation (CY/TBI), CY/TBI+cytarabine (AraC), or CY/TBI+etoposide (VP16) were included.
RESULTS: The acute myeloid leukemia (AML) cohort (
CONCLUSION: In AML adding AraC and VP16 to CY/TBI had an adverse effect on OS. Conversely, in ALL, adding VP16 or AraC to CY/TBI did not affect survival, but the addition of VP16 reduced the risk of relapse.
CLINICAL TRIAL REGISTRATION: The authors have confirmed clinical trial registration is not needed for this submission.
Volume
6
Issue
3
First Page
70061
Last Page
70061
ISSN
2688-6146
Published In/Presented At
Arai, Y., Brazauskas, R., He, N., Al-Homsi, A. S., Chhabra, S., Battiwalla, M., Yanada, M., Steinberg, A., Diaz Perez, M. A., Hong, S., Kanda, J., Bashey, A., Frangoul, H. A., Badawy, S. M., Verdonck, L. F., Lazarus, H. M., Yared, J. A., Hashem, H., Sharma, A., Aljurf, M., … Saber, W. (2025). Efficacy of Total-Body Irradiation-based Intensified Myeloablative Regimens for Acute Leukemia-An International Collaborative Study. EJHaem, 6(3), e70061. https://doi.org/10.1002/jha2.70061
Disciplines
Medicine and Health Sciences
PubMedID
40438703
Department(s)
Department of Medicine, Hematology-Medical Oncology Division, Lehigh Valley Topper Cancer Institute
Document Type
Article