Emerging and Clinically Accepted Biomarkers for Hepatocellular Carcinoma.
Publication/Presentation Date
4-10-2024
Abstract
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death and the sixth most diagnosed malignancy worldwide. Serum alpha-fetoprotein (AFP) is the traditional, ubiquitous biomarker for HCC. However, there has been an increasing call for the use of multiple biomarkers to optimize care for these patients. AFP, AFP-L3, and prothrombin induced by vitamin K absence II (DCP) have described clinical utility for HCC, but unfortunately, they also have well established and significant limitations. Circulating tumor DNA (ctDNA), genomic glycosylation, and even totally non-invasive salivary metabolomics and/or micro-RNAS demonstrate great promise for early detection and long-term surveillance, but still require large-scale prospective validation to definitively validate their clinical validity. This review aims to provide an update on clinically available and emerging biomarkers for HCC, focusing on their respective clinical strengths and weaknesses.
Volume
16
Issue
8
ISSN
2072-6694
Published In/Presented At
Fares, S., Wehrle, C. J., Hong, H., Sun, K., Jiao, C., Zhang, M., Gross, A., Allkushi, E., Uysal, M., Kamath, S., Ma, W. W., Modaresi Esfeh, J., Linganna, M. W., Khalil, M., Pita, A., Kim, J., Walsh, R. M., Miller, C., Hashimoto, K., Schlegel, A., … Aucejo, F. (2024). Emerging and Clinically Accepted Biomarkers for Hepatocellular Carcinoma. Cancers, 16(8), 1453. https://doi.org/10.3390/cancers16081453
Disciplines
Medicine and Health Sciences
PubMedID
38672535
Department(s)
Department of Medicine
Document Type
Article