Circulating tumor DNA in management of primary liver malignancy: A review of the literature and future directions.
Publication/Presentation Date
4-1-2025
Abstract
Primary liver malignancies are a serious and challenging global health concern. The most common primary tumors are hepatocellular carcinoma and cholangiocarcinoma. These diseases portend poor prognosis when presenting with progressive, extensive disease. There is a critical need for improved diagnosis, therapeutic intervention, and monitoring surveillance in liver-related malignancies. Liquid biopsy using ctDNA provides an opportunity for growth within these domains for liver-related malignancy. However, ctDNA is relatively understudied in this field compared with other solid tumor types, possibly due to the complex nature of the pathology. In this review, we aim to discuss ctDNA, the current literature, and future directions of this technology within primary liver malignancies.
Volume
131
Issue
5
First Page
879
Last Page
887
ISSN
1096-9098
Published In/Presented At
Tocci, N. X., Wehrle, C. J., Sun, K., Jiao, C., Hong, H., Gross, A., Allkushi, E., Uysal, M., Linganna, M. W., Stackhouse, K., Hashimoto, K., Schlegel, A., Walsh, R. M., Miller, C., Kwon, D. C. H., & Aucejo, F. (2025). Circulating tumor DNA in management of primary liver malignancy: A review of the literature and future directions. Journal of surgical oncology, 131(5), 879–887. https://doi.org/10.1002/jso.27825
Disciplines
Medicine and Health Sciences
PubMedID
39155663
Department(s)
Department of Medicine
Document Type
Article